Fresh analysis indicates that patients who discontinue blockbuster weight-loss injections like Mounjaro or Wegovy may regain reduced body mass far faster than those who end conventional diet and exercise programs.
Findings released in a leading medical journal demonstrates that while obese individuals frequently drop a large proportion of their body weight while undergoing treatment, the weight is regained at an average rate of 0.8 kg per month after stopping.
"Users using these medications should be informed of the potential of quick rebound weight gain when the treatment is stopped," cautioned researcher Dr. Susan Jebb.
Such speed of recovery suggests a return to original weight within about 18 months.
Weighing Therapies
The study, which reviewed 37 of trials involving over 9,000 of patients, contrasted the effects of the injectable medications with conventional dieting.
Scientists note that individuals who lose weight through dieting generally have a less rapid weight regain—around 100 grams monthly—after stopping.
The Reason for the Rapid Rebound
Nutrition scientists propose the way of the jabs is key to understanding the heightened rebound.
These medications copy a natural hormone called GLP-1, which controls appetite.
"Long-term administration of GLP-1 levels far above than normal may cause the system to generate a reduced amount of its own natural hormone, and may also reduce responsiveness to its effects," noted Dr. Adam Collins, a nutrition researcher.
"Stopping of this medication means appetite is unsuppressed, making binge eating a significant risk."
A Lifelong Condition?
Health authorities advise the jabs for people with obesity-related health risks, accompanied by prescribed diet and exercise modifications.
Many experts contend that, due to the likelihood of relapse, the treatment should be considered ongoing.
This perspective is supported by drug manufacturers, who note that the results "underscore the persistent character of obesity," comparing it to managing conditions like high blood pressure.
User Experiences
People who have stopped the jabs describe a powerful resurgence of appetite.
"It felt as if a trigger activating and you're instantly starving," recalled a patient.
This difficulty is exacerbated if individuals have not adopted permanent lifestyle or habit changes during therapy.
Widespread Use
Survey data indicate that a significant number of adults in the UK have used these injections in the last 12 months, with demand continuing to grow.
- Use is greater among women than men.
- The 40s and 50s age group shows the highest usage rates.
- Many obtain the drugs through private healthcare rather than public health services.
In conclusion, researchers caution that while GLP-1 drugs are effective tools for weight loss, they are not a magic fix and long-term success relies on combined lifestyle management.
